HLA-DRB1 genotyping in patients with juvenile idiopathic arthritis in Taiwan

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Summary

The object of this study was to investigate whether there is an association between HLA-DRB1 alleles and the development of juvenile idiopathic arthritis (JIA) in Taiwan. HLA-DRB1 alleles were studied in 60 patients with JIA and 200 healthy controls using polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (SSO). The frequency of HLA-DRB1*0405 in patients with JIA was found to be significantly higher than that in healthy controls [odds ratio (OR) 2.64, 95% confidence interval (CI) 1.01–6.91]. The DRB1*0405 allele was significantly associated with the development of both polyarthritis (OR 4.30, 95% CI 1.34–13.80) and oligoarthritis (OR 3.27, 95% CI 1.01–10.58). The frequency of HLA-DRB1*1502 was higher in Taiwanese JIA patients with systemic arthritis than in controls (OR 18.09, 95% CI 2.25–145.73). We conclude that, in Taiwan, HLA-DRB1*0405 is associated with the development of polyarthritis and oligoarthritis in children, and HLA-DRB1*1502 is associated with the development of systemic arthritis.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-2370.2004.00467.x

Affiliations: 1:  Department of Pediatrics, Chang Gung University and Chang Gung Children's Hospital, Taoyuan, Taiwan, 2:  Immunogenetic Laboratory, Tzu Chi Foundation, Hualien, Taiwan, and 3:  Department of Microbiology and Immunology, Graduate Institute of Basic Medical Research, Chang Gung University, Taoyuan, Taiwan.

Publication date: August 1, 2004

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more