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Identification of two novel single nucleotide polymorphisms in the promoter of the human interleukin-18 receptor α

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Summary

Single-strand conformational polymorphism (SSCP) was used to identify single nucleotide polymorphisms (SNPs) in the promoter region of the human interleukin-18 receptor α (IL-18Rα). Two SNPs were identified at positions −69 and −638 relative to the transcriptional start site. Two-way comparison of the two SNPs revealed strong linkage disequilibrium (2 = 63.45, P < 0.001). Three haplotypes were identified, namely C−69C−638, T−69C−638 and C−69T−638, with frequencies of 0.26, 0.39 and 0.35, respectively.
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Document Type: Research Article

Publication date: 01 February 2004

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