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Allele-specific binding to the −308 single nucleotide polymorphism site in the tumour necrosis factor-alpha promoter

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Single nucleotide polymorphisms in the tumour necrosis factor alpha (TNF-α) promoter region may modulate TNF-α gene transcriptional activity by modifying the binding of transcription factors. Here we confirm that a specific DNA complex binds preferentially the variant TNF2 allele in various cell types and demonstrate that activating protein (AP)-2, myeloid zinc finger gene 1 (MZF-1) and Sp1 are not involved in this complex.
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Document Type: Research Article

Publication date: 01 February 2004

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