Allele-specific binding to the −308 single nucleotide polymorphism site in the tumour necrosis factor-alpha promoter
Authors: Baseggio, L.; Bartholin, L.; Chantome, A.; Charlot, C.; Rimokh, R.; Salles, G.
Source: European Journal of Immunogenetics, Volume 31, Number 1, February 2004 , pp. 15-19(5)
Single nucleotide polymorphisms in the tumour necrosis factor alpha (TNF-α) promoter region may modulate TNF-α gene transcriptional activity by modifying the binding of transcription factors. Here we confirm that a specific DNA complex binds preferentially the variant TNF2 allele in various cell types and demonstrate that activating protein (AP)-2, myeloid zinc finger gene 1 (MZF-1) and Sp1 are not involved in this complex.
Document Type: Research Article
Publication date: 2004-02-01