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Analysis of the CC chemokine receptor 5 (CCR5) Δ32 polymorphism in Behçet's disease

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Abstract:

Summary

Chemokines are important determinants of the early inflammatory response. The CC chemokine receptor 5 (CCR5) Δ32 variant results in a non-functional form of the chemokine receptor, and has been implicated in a variety of immune-mediated diseases. To investigate its role in the pathogenesis of Behçet's disease, we studied 350 patients and 519 healthy controls from three ethnic groups. While significant inter-ethnic variation in allele frequency was observed, no association was identified with disease, even when data were stratified by the known susceptibility gene HLA-B*51.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-2370.2004.00444.x

Publication date: February 1, 2004

bsc/ejimm/2004/00000031/00000001/art00003
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