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Analysis of the CC chemokine receptor 5 (CCR5) Δ32 polymorphism in Behçet's disease

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Summary

Chemokines are important determinants of the early inflammatory response. The CC chemokine receptor 5 (CCR5) Δ32 variant results in a non-functional form of the chemokine receptor, and has been implicated in a variety of immune-mediated diseases. To investigate its role in the pathogenesis of Behçet's disease, we studied 350 patients and 519 healthy controls from three ethnic groups. While significant inter-ethnic variation in allele frequency was observed, no association was identified with disease, even when data were stratified by the known susceptibility gene HLA-B*51.
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Document Type: Research Article

Publication date: 2004-02-01

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