Expression of low-frequency Ala108Pro substitution in the platelet glycoprotein Ibβ gene

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We determined the gene frequency of the glycoprotein (GP) Ibβ Ala108Pro substitution. The Pro108 allele was not found in 208 healthy Japanese and 200 healthy Caucasians. In vitro expression studies showed surface expression of the GPIbβ Pro108 variant, suggesting the possibility of the involvement of the substitution as an alloantigen.

Document Type: Research Article


Publication date: April 1, 2003

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