Further support for the association of CCR5 allelic variants with asthma susceptibility
English and German nuclear families containing multiple asthmatic children and asthmatic parents were analysed to retest a recently reported association between resistance to asthma and the Δ32 allele of chemokine receptor 5 (CCR5). Analysis of the families by the transmission-disequilibrium test (TDT) revealed a non-significant trend in the English families that provided marginal confirmation of the association (P < 0.125), but no similar trend was observed in the German families. Case–control comparison of Δ32 allele and genotype frequencies in asthmatic vs. non-asthmatic parents revealed a significantly lower frequency of Δ32 in asthmatic English parents (P < 0.009) and a similar but non-significant trend in German parents (P < 0.265). Taken together, the pattern of results provides confirmation for the previously observed Δ32–asthma association and indicates that susceptibility to asthma may be influenced by CCR5 or another gene in chromosomal region 3p21.
Document Type: Research Article
Publication date: 2002-12-01