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Polymorphism in the promoter region of the gene encoding human allograft inflammatory factor-1

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Abstract:

Summary

We have identified a new single nucleotide polymorphism within the promoter region of the human allograft inflammatory factor (AIF-1) gene. The polymorphism, defined by Genbank accession number AF097515, was characterized as a C/T single base pair substitution at position −932. The T allele is associated with both HLA-DR2 and HLA-B7. Also, this allele creates the consensus binding site for the E-box that has high affinity for the basic helix-loop-helix (bHLH) family of transcription factors.

Document Type: Research Article

Publication date: August 1, 2001

bsc/ejimm/2001/00000028/00000004/art00002
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