Intercellular adhesion molecule-1 gene polymorphisms in Behçet's disease
Authors: Verity, D. H.; Vaughan, R. W.; Kondeatis, E.; Madanat, W.; Zureikat, H.; Fayyad, F.; Marr, J. E.; Kanawati, C. A.; Wallace, G. R.; Stanford, M. R.
Source: European Journal of Immunogenetics, Volume 27, Number 2, April 2000 , pp. 73-76(4)
Abstract:Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms have been implicated in the susceptibility to inflammatory diseases, including multiple sclerosis and inflammatory bowel disease. The expression of both soluble and tissue ICAM-1 is increased in Behçet's disease (BD) but the contribution of ICAM-1 gene polymorphisms to this disease remains unknown. Associations with BD have been reported for genes within the MHC, including HLA-B51, TNF and MICA, but the role of non-MHC genes in BD remains largely unexplored. We have investigated the frequency of the R/G 241 and K/E 469 ICAM-1 gene polymorphisms in 83 patients with BD disease and 103 healthy controls, all of Palestinian and Jordanian descent, and demonstrated an association between BD and the ICAM-1 E469 allele (Pc = 0.046, OR = 2.1). Among patients, no association was found between the presence of ocular disease and ICAM-1 polymorphisms. While the functional correlate of this polymorphism remains unclear, this finding indicates that a genetic polymorphism in the ICAM-1 gene domain, which is independent of the MHC, may contribute to disease.
Document Type: Research article
Publication date: 2000-04-01