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A polymorphic major histocompatibility complex class II-like locus maps outside of both the chicken B-system and Rfp-Y-system

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Abstract:

Abstract

Chickens have two major regions encoding major histocompatibility complex (MHC) class Iα genes and MHC class IIß genes, the serological and functional B-system and the Rfp-Y-system. Recently, they have been shown to assort in a genetically independent way although still located on the same microchromosome. Moreover, the monomorphic MHC class IIα gene maps at a third locus located 5 cmfrom the nearest class IIß genes, located in the B-system ( Kaufman et al., 1995 ). A pedigree family was studied in three generations in order to assign MHC class IIß restriction fragments observed in Southern blot analyses to either the B-system, the Rfp-Y-system or the B-Lα locus. In this study, we demonstrate by classical genetic testing of chickens within this fully pedigreed family the existence of an MHC class II-like polymorphic restriction fragment that segregates independently of the B-system, the Rfp-Y-system and of the B-Lα locus.

Document Type: Research Article

DOI: http://dx.doi.org/10.1046/j.1365-2370.2000.00200.x

Publication date: April 1, 2000

bsc/ejimm/2000/00000027/00000002/art00002
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