Dinucleotide repeat polymorphisms within the Flt-1 gene in minimal change nephropathy

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Abstract:

Abstract

Dysregulation of Flt-1, a major receptor for vascular permeability factor (VPF), may provide a mechanism for the development of proteinuria in minimal change nephropathy (MCN). The gene for Flt-1 has a polymorphic dinucleotide repeat. We have demonstrated an 88% predominance of one allele and an 80% rate of homozygosity for this polymorphism with no association with MCN.

Document Type: Research Article

DOI: http://dx.doi.org/10.1046/j.1365-2370.1999.00161.x

Publication date: October 1, 1999

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