Dinucleotide repeat polymorphisms within the Flt-1 gene in minimal change nephropathy
Dysregulation of Flt-1, a major receptor for vascular permeability factor (VPF), may provide a mechanism for the development of proteinuria in minimal change nephropathy (MCN). The gene for Flt-1 has a polymorphic dinucleotide repeat. We have demonstrated an 88% predominance of one allele and an 80% rate of homozygosity for this polymorphism with no association with MCN.
Document Type: Research Article
Publication date: October 1, 1999