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In vitro production of IFN-γ correlates with CA repeat polymorphism in the human IFN-γ gene

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The DNA sequence of the human IFN-γ gene shows the presence of a variable-length CA repeat in the first intron of the gene. We investigated the allele distribution of this microsatellite region in 164 unrelated healthy individuals, and the association with interferon-γ (IFN-γ) production. In vitro production of IFN-γ showed a significant correlation with the presence of allele #2.

Document Type: Original Article


Affiliations: 1: School of Biological Sciences, University of Manchester, UK and, 2: Tissue Typing Laboratory, St Mary‘s Hospital, Manchester, UK.

Publication date: 1999-02-01

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