In vitro production of IFN-γ correlates with CA repeat polymorphism in the human IFN-γ gene
Abstract:The DNA sequence of the human IFN-γ gene shows the presence of a variable-length CA repeat in the first intron of the gene. We investigated the allele distribution of this microsatellite region in 164 unrelated healthy individuals, and the association with interferon-γ (IFN-γ) production. In vitro production of IFN-γ showed a significant correlation with the presence of allele #2.
Document Type: Original Article
Publication date: 1999-02-01