Two novel biallelic polymorphisms in the IL-2 gene

Authors: John, S.¹; Turner, D.²; Donn, R.¹; Sinnott, P.³; Worthington, J.¹; Ollier, W. E. R.¹; Hutchinson, I. V.⁴; Hajeer, A. H.¹

Source: European Journal of Immunogenetics, Volume 25, Number 6, December 1998 , pp. 419-420(2)

Publisher: Wiley-Blackwell

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Abstract:

We have detected two novel single nucleotide polymorphisms in the IL-2 gene, at positions -330 and +166 relative to the transcription start site. The +166 change occurs within the leader peptide and does not affect amino acid sequence. The -330 polymorphism has two common alleles, making it an ideal marker for genetic association studies.

Document Type: Short communication

DOI: http://dx.doi.org/10.1046/j.1365-2370.1998.00139.x

Affiliations: 1: ARC Epidemiology Research Unit, Stopford Building, Oxford Road, Manchester M13 9PT, UK, 2: National Blood Service, North London Centre, Colindale Avenue, London NW9 5BG, UK, 3: Tissue Typing Laboratory, The Royal London Hospital, 55-76 Ashfield Street, Whitechapel, London E1 1BB, UK. 4: Immunology Group, School of Biological Sciences, Stopford Building, Oxford Road, Manchester M13 9PT, UK, and,

Publication date: 1998-12-01