A study of HLA-DPB1 phenotypes reveals DPB1*6301 in a rural population from Cameroon

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Abstract:

Several recently reported HLA-DPB1 alleles have only been identified in a single family or individuals and are of unknown distribution world-wide. Many new DPB1 alleles appear to arise as a result of gene conversion-like events, which may localize variant DPB1 alleles to the population in which they were first identified. Using two SSOP-based typing methods in parallel, we have identified HLA-DPB1*6301 in an individual from rural Cameroon which has previously only been reported in a family of Mexican-American origin. The presence of DPB1*6301 was confirmed by sequence-based typing of exon 2.

Document Type: Short Communication

DOI: http://dx.doi.org/10.1046/j.1365-2370.1998.00114.x

Affiliations: 1: ARC Epidemiology Research Unit, Manchester University, Stopford building, Oxford Road, Manchester M13 9PT, UK;, 2: UKTSSA, Bristol, UK and, 3: Diabetes Research Laboratory, University of Yaounde I,Yaounde, Cameroon.

Publication date: October 1, 1998

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