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Complement C4B null allele status confers risk for systemic lupus erythematosus in a Spanish population

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Genetic susceptibility to systemic lupus erythematosus (SLE) may vary amongst different populations. In UK patients, genes encoded in the HLA class II (DQA*0501/DRB1*0301) and class III [C4A*Q0 and tumour necrosis factor (TNF) polymorphisms] subregions appear to contribute to disease susceptibility. We have examined HLA-DRB1, C4 and TNF microsatellites in 50 Spanish SLE patients and 48 matched controls. HLA-DRB1*0301 was increased in patients but did not achieve statistical significance (41% vs. 25.5%). C4A*Q0 was not increased in patients, but C4B*Q0 allele frequency was significantly increased compared with the controls (29% vs. 6%; OR: 6.0). TNF c2 microsatellite allele frequency was also increased in SLE patients. The C4B null allele (C4B*Q0) appears to play an important role in SLE susceptibility in the Spanish population.
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Document Type: Short Communication

Affiliations: 1: Unidad de Investigacion, Hospital Central de Asturias, 33006 Oviedo, Spain, 2: ARC ERU, Stopford Building, Manchester M13 9PT, UK, 3: Department of Rheumatology, Blackburn Royal Infirmary, Bolton Road, Blackburn BB2 3LR, UK, 4: Hospital Val d’Hebron, Barcelona, Spain.

Publication date: 01 August 1998

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