Complement C4B null allele status confers risk for systemic lupus erythematosus in a Spanish population
Genetic susceptibility to systemic lupus erythematosus (SLE) may vary amongst different populations. In UK patients, genes encoded in the HLA class II (DQA*0501/DRB1*0301) and class III [C4A*Q0 and tumour necrosis factor (TNF) polymorphisms] subregions appear to contribute to disease susceptibility. We have examined HLA-DRB1, C4 and TNF microsatellites in 50 Spanish SLE patients and 48 matched controls. HLA-DRB1*0301 was increased in patients but did not achieve statistical significance (41% vs. 25.5%). C4A*Q0 was not increased in patients, but C4B*Q0 allele frequency was significantly increased compared with the controls (29% vs. 6%; OR: 6.0). TNF c2 microsatellite allele frequency was also increased in SLE patients. The C4B null allele (C4B*Q0) appears to play an important role in SLE susceptibility in the Spanish population.
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Document Type: Short Communication
Unidad de Investigacion, Hospital Central de Asturias, 33006 Oviedo, Spain,
ARC ERU, Stopford Building, Manchester M13 9PT, UK,
Department of Rheumatology, Blackburn Royal Infirmary, Bolton Road, Blackburn BB2 3LR, UK,
Hospital Val d’Hebron, Barcelona, Spain.
Publication date: 01 August 1998