Authors: Vítek, L.¹; Carey, M. C.²

Source: European Journal of Clinical Investigation, Volume 33, Number 9, September 2003 , pp. 799-810(12)

Publisher: Wiley-Blackwell

Abstract:

In contrast to bile salts, which undergo a highly efficient enterohepatic circulation with multiple regulatory and physiologic functions, glucuronic acid conjugates of bilirubin are biliary excretory molecules that in health do not have a continuing biologic life. Intestinal absorptive cells are devoid of recapture transporters for bilirubin conjugates, and their large size and polarity prevent absorption by passive diffusion. However, unconjugated bilirubin, the β-glucuronidase hydrolysis product of bilirubin glucuronides can be absorbed passively from any part of the small and large intestines. This can occur only if unconjugated bilirubin is kept in solution and does not undergo rapid bacterial reduction to form urobilinoids. Here we collect, and in some cases reinterpret, experimental and clinical evidence to show that in addition to the well-known occurrence in newborns, enterohepatic cycling of unconjugated bilirubin can reappear in adult life. This happens as a result of several common conditions, particularly associated with bile salt leakage from the small intestine, the most notable ileal dysfunction resulting from any medical or surgical cause. We propose that when present in excess, colonic bile salts solubilize unconjugated bilirubin, delay urobilinoid formation, prevent calcium complexing of unconjugated bilirubin and promote passive absorption of unconjugated bilirubin from the large intestine. Following uptake, reconjugation, and resecretion into bile, this source of `hyperbilirubinbilia' may be the important pathophysiological risk factor for `black' pigment gallstone formation in predisposed adult humans.

Keywords: Bile salt malabsorption; bilirubin; Crohn's disease; enterohepatic circulation; Gilbert syndrome; ileal disease; intestinal microflora; pigment gallstones

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1365-2362.2003.01214.x

Affiliations: 1: Charles University of Prague, Prague, Czech Republic, 2: Brigham and Women's Hospital, Boston, MA

Publication date: 2003-09-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Public Health
• By this author: Vítek, L. ;  Carey, M. C.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers