IngentaConnect Microvascular angina (cardiological syndrome X) per se is not ass...

Authors: Cavallo Perin P.¹; Pacini G.²; Giunti S.³; Comune M.¹; Conte M.R.⁴; Cassader M.¹; Pagano G.¹; Perin P.C.^*

Source: European Journal of Clinical Investigation, Volume 30, Number 6, June 2000 , pp. 481-486(6)

Abstract:

Background

Microvascular angina has been found to be associated with insulin resistance. However, many factors known to affect insulin sensitivity were not excluded in patient selection. We aimed to evaluate whether microvascular angina is per se associated with insulin resistance.

Materials and methods

We performed a Frequently Sampled Intravenous Glucose Tolerance Test (0.33 g kg^-1 b.w.) in 10 normal weight and normotensive patients with microvascular angina, with normal glucose tolerance and normal plasma lipids. Ten healthy subjects, comparable for age, sex, body mass index, blood pressure and plasma lipids, were used as control group.

Results

Fasting serum glucose (4.49 ± 0.2 SEM vs. 4.52 ± 0.13 mmol L^-1, P = 0.9), insulin (39.46 ± 3.68 SEM vs. 47.12 ± 4.6 pmol L^-1, P = 0.21) and C-peptide (0.56 ± 0.05 SEM vs. 0.53 ± 0.05 nmol L^-1, P = 0.68) values, as well as estimated parameters of insulin secretion and hepatic insulin extraction were similar in the two groups. Insulin sensitivity values (median, range) were also similar in the patients and control subjects (5.76 (3.39–12.30) vs. 7.54 (3.68–13.89. 10^-4. min^-1/( mgr U/mL), P = 0.97).

Conclusion

Microvascular angina per se is not associated with hyperinsulinaemia or insulin resistance when other confounding factors are excluded in patient selection.

Keywords: Insulin resistance; microvascular angina; minimal models

Language: English

Document Type: Research article

Affiliations: 1: University of Turin, Turin, Italy 2: Institute of Systems Science and Biomedical Engineering (LADSEB-CNR), Padova, Italy 3: Salute e Politiche Sociali della Regione autonoma Valle d'Aosta, Italy 4: Cardiology Unit, Rivoli, Italy *

Microvascular angina (cardiological syndrome X) per se is not associated with hyperinsulinaemia or insulin resistance