NADH/NADPH oxidase p22 phox C242T polymorphism and coronary artery disease in the Australian population

Authors: Cai H.¹; Duarte N.¹; Wilcken D.E.L.¹; Wang X.L.¹; Li Wang X.^*

Source: European Journal of Clinical Investigation, Volume 29, Number 9, September 1999 , pp. 744-748(5)

Publisher: Wiley-Blackwell

Abstract:

Oxidative stress induced by the superoxide anion (.O₂^-) has been implicated in atherogenesis. The NADH/NADPH oxidase system is involved in .O₂^- production and p22 phox is an essential component of that system.

We analysed the p22 phox C242T polymorphism in 689 consecutive Australian Caucasians aged 65 years with and without angiographically documented coronary artery disease (CAD)

We report the rare T allele frequency of 0.33, which is 3 fold higher than that reported in the Japanese population by Inoue et al. [7]. The genotype distributions were not different among patients with CAD (CC:0.422, CT:0.459 and TT: 0.119 in men; 0.447, 0.439 and 0.114 in women) and without CAD (0.479, 0.420 and 0.101%, ² = 0.794, P = 0.672 in men; 0.443, 0.471 and 0.86, ² = 0.442, P = 0.802 in women). The frequencies of the rare TT homozygotes or of the ‘T’ allele frequency were also not associated with the number of significantly stenosed vessels (² = 4.466, P = 0.614 in men; ² = 4.736, P = 0.578 in women) or with a myocardial infarction (MI) history (² = 2.310, P = 0.315 in men; ² = 1.178, P = 0.555 in women). However, when the analysis was conducted in young male patients aged 45 years (n = 44), TT + TC patients tended to have an increased risk for CAD (odds ratio: 5.71 95% CI: 1.22–26.75, P = 0.0271).

The p22 phox C242T polymorphism is not associated with the occurrence or severity of CAD or with a history of MI in Australian Caucasian patients aged 65 years. However, the polymorphism could be associated with an increased CAD risk in young patients, which requires confirmation in large populations.

Keywords: coronary artery disease; ethnic difference; NADH/NADPH p22 phox polymorphism

Language: English

Document Type: Research article

Affiliations: 1: Cardiovascular Genetics Laboratory, Prince of Wales Hospital, Centre for Thrombosis and Vascular Research, University of New South Wales, Sydney, Australia *

Publication date: 1999-09-01

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• In this Subject: Public Health
• By this author: Cai H. ;  Duarte N. ;  Wilcken D.E.L. ;  Wang X.L. ;  Li Wang X.

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