Skip to main content

Vasodilator responses to nitric oxide are enhanced in mesenteric arteries of portal hypertensive rats

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Abstract. Nitric oxide (NO) is discussed as a mediator of the splanchnic hyperaemia in portal hypertension. We assessed the vasorelaxation by the NO-dependent vasodilator acetylcholine, the NO donor 3-morpholino-sydnonimine (SIN-1) and forskolin, a stimulator of the adenylate cyclase pathway in potassium-preconstricted isolated perfused mesenteric arteries of portal vein-ligated and sham-operated rats. Dilator responses to acetylcholine and SIN-1 were significantly enhanced in vessels of portal vein-ligated rats as compared to sham-operated rats, whereas no difference was found in forskolin-induced vasodilatation. This suggests enhanced reactivity of the vasculature to NO in experimental portal hypertension.

Keywords: 3-morpholino-sydnonimine (SIN-1); Acetylcholine; forskolin; nitric oxide; portal hypertensive rats; vasodilatation

Document Type: Rapid Communication

DOI: http://dx.doi.org/10.1046/j.1365-2362.1996.2340557.x

Affiliations: Department of Medicine,

Publication date: September 1, 1996

bsc/ejci/1996/00000026/00000009/art00013
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more