Skip to main content

Vasodilator responses to nitric oxide are enhanced in mesenteric arteries of portal hypertensive rats

Buy Article:

$51.00 plus tax (Refund Policy)


Abstract. Nitric oxide (NO) is discussed as a mediator of the splanchnic hyperaemia in portal hypertension. We assessed the vasorelaxation by the NO-dependent vasodilator acetylcholine, the NO donor 3-morpholino-sydnonimine (SIN-1) and forskolin, a stimulator of the adenylate cyclase pathway in potassium-preconstricted isolated perfused mesenteric arteries of portal vein-ligated and sham-operated rats. Dilator responses to acetylcholine and SIN-1 were significantly enhanced in vessels of portal vein-ligated rats as compared to sham-operated rats, whereas no difference was found in forskolin-induced vasodilatation. This suggests enhanced reactivity of the vasculature to NO in experimental portal hypertension.

Keywords: 3-morpholino-sydnonimine (SIN-1); Acetylcholine; forskolin; nitric oxide; portal hypertensive rats; vasodilatation

Document Type: Rapid Communication


Affiliations: Department of Medicine,

Publication date: September 1, 1996


Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more