Neonatal skin barrier: structure, function, and disorders
Authors: Shwayder, Tor; Akland, Tom
Source: Dermatologic Therapy, Volume 18, Number 2, March 2005 , pp. 87-103(17)
The development of the human skin from intrauterine to extrauterine life is a balletic interplay of maturing layers and interlocking structures. We discuss this transition and then branch out to touch on issues of premature infant as well as neonatal skin care. Disruption of the barrier function due to toxins and development errors are expounded upon. Staph scalded skin syndrome, collodion membrane, bullous congenital ichthyosiform erythroderma, autosomal recessive ichthyosis (lamellar and congenital ichthyosiform erythroderma), and harlequin fetus are used as examples of these disruptions. Discussion of therapy with the authors’ experience highlights each disease.
Keywords: Neonatal skin; Staphylococcal scalded-skin syndrome; barrier function; bullous and non-bullous congenital ichthyosiform erythroderma; collodion membrane; harlequin fetus; lamellar ichthyosis; nosocomial infections; premature infant skin
Document Type: Research Article
Affiliations: Pediatrics, Sparrow Hospital, Lansing, MI
Publication date: March 2005