Authors: KADUNC, BOGDANA VICTORIA; TRINDADE DE ALMEIDA, ADA REGINA; VANTI, ADRIANA AMORIN; DI CHIACCHIO, NILTON

Source: Dermatologic Surgery, Volume 33, Number 9, September 2007 , pp. 1066-1072(7)

Publisher: Wiley-Blackwell

Abstract:

BACKGROUND

The treatment of perioral vertical wrinkles is a very common request from female patients as of their 40th decade of life. Actinic damage, cigarette smoking, loss of deep structures volume, sleep positions, orthodontic deformities, and dynamic components have been thought to cause this aesthetic problem. OBJECTIVE

The objective was to investigate the combination of botulinum toxin type A (BoNTA) pretreatment of the orbicularis oris muscle with manual chemabrasion to increase its clinical efficacy in the therapy of upper perioral vertical rhytides. METHODS

Twelve women presenting moderate to severe upper lip vertical rhytides were randomized to receive two unilateral BoNTA injections at the vermilion border, 1 week before chemabrasion (35% trichloroacetic acid followed by dermasanding) of the upper perioral cosmetic unit. Wrinkle severity was assessed by two blinded observers at baseline, 30 days, 90 days, 180 days, and 3 years by using a four-point Facial Wrinkle Severity Scale (FWSS). RESULTS

From Day 90 to Year 3, the BoNTA-injected sides showed smaller grades in the FWSS than control sides (p<.05). CONCLUSION

Previous injections of BoNTA improve short- and long-term results of chemabrasion in the upper lip region.

Ada Almedia, MD, is a consultant and speaker for Allergan, South America.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1524-4725.2007.33220.x

Affiliations: 1: Dermatologic Clinic, Hospital do Servidor Publico Municipal, São Paulo, Brazil

Publication date: 2007-09-01

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