Topical Imiquimod as an Adjuvant to Laser Removal of Mature Tattoos in an Animal Model

Authors: RAMIREZ, MARK¹; MAGEE, NORMA²; DIVEN, DAYNA¹; COLOME-GRIMMER, MARIA¹; MOTAMEDI, MASSOUD³; OLIVEIRA, GISELE³; ZAMORA, JESUS G.⁴; UCHIDA, TATSUO⁵; WAGNER, RICHARD F.¹

Source: Dermatologic Surgery, Volume 33, Number 3, March 2007 , pp. 319-325(7)

Publisher: Wiley-Blackwell

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Abstract:

BACKGROUND

Lasers are a commonly employed method of tattoo removal; however, numerous treatments are often needed and laser treatment may fail to eliminate the tattoo completely. It has been shown in animal studies that topical application of imiquimod cream, alone, fades tattoos. It is suspected that the combination of both imiquimod and laser treatment will result in enhanced tattoo pigment clearance. OBJECTIVE

The objective was to evaluate the efficacy of topical imiquimod cream as an adjuvant to laser removal of mature tattoos. METHODS

Fourteen albino guinea pigs were tattooed with black ink, then randomly assigned into two groups: one underwent sequential laser treatments with a Q-switched alexandrite laser in conjunction with triweekly applications of 5% imiquimod cream, while the other group underwent laser therapy alone. Subjects were evaluated with clinical photographs and skin biopsies after six laser treatment sessions. RESULTS

The combination laser and imiquimod treated group was clinically and histologically rated as having less pigment than the tattoos that were treated with laser alone (p=.012 and p=.047, respectively). Adjuvant imiquimod treatment had greater inflammation (p=.002) and fibrosis (p=.002) on posttreatment skin biopsies. CONCLUSION

Imiquimod appears to be a useful adjuvant to experimental laser tattoo removal in guinea pigs.

The imiquimod 5% cream used in this study was provided by 3 M Pharmaceuticals (St. Paul, MN).

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1524-4725.2007.33067.x

Affiliations: 1: Department of Dermatology, 2: Department of Dermatology, Louisiana State University, New Orleans, Louisiana; 3: Department of Surgery, and 4: Department of Radiology, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 5: Office of Biostatistics, The University of Texas Medical Branch, Galveston, Texas;

Publication date: 2007-03-01

Topical Imiquimod as an Adjuvant to Laser Removal of Mature Tattoos in an Animal Model

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