Background. Cutaneous mucinosis can be a primary or secondary reaction, as seen in connective tissue diseases, lupus erythematosus, metabolic diseases, paraproteinemias, and even malignant lymphomas. Objective. Focal cutaneous mucinosis usually arises as a result of the dysfunction of fibroblasts in a local area. It may arrive from various mechanical stimulations. Methods. We presented an unusual heretofore unreported case of a polypoid mucinosis. Conclusion. The local mucin deposition in this patient was considered as a secondary change from frequent friction by clothes. H.-H. CHEN, MD, C.-J. CHUNG, MD, T.-T. KUO, MD, PHD, AND H.-S. HONG, MD, PHD HAVE INDICATED NO SIGNIFICANT INTEREST WITH COMMERCIAL SUPPORTERS.