@article {Hiramatsu:May 2004:1462-8902:231,
	author = "Hiramatsu, S.",
	author = "Tajiri, Y.",
	author = "Karashima, T.",
	title = "Lower plasma adiponectin concentration predicts the efficacy of pioglitazone in diabetic patients",
	journal = "Diabetes, Obesity and Metabolism",
	volume = "6",
	year = "May 2004",
	abstract = "Aim:&#8194; <P></P>To investigate clinical efficacy of pioglitazone in association with plasma adiponectin concentration in type 2 diabetic patients. Methods:&#8194; <P></P>Ten diabetic patients were treated with 15 or 30&#8201;mg of pioglitazone for 8 weeks, and association between plasma adiponectin concentration before treatment and decrease in glycated albumin levels was examined. Results:&#8194; <P></P>Treatment with pioglitazone for 8 weeks lowered glycated albumin level (27.1&#8201;&#177;&#8201;1.2 to 23.8&#8201;&#177;&#8201;1.4%, p&#8201;&#60;&#8201;0.05), and inverse relationship between changes in glycated albumin and plasma adiponectin concentration before treatment was revealed (r&#8201;&#61;&#8201;&#8722;0.66, p&#8201;&#60;&#8201;0.05). Plasma adiponectin concentrations of patients whose glycated albumin level reduced by more than 10% of the levels before treatment were significantly lower than those of patients whose glycaemic control was affected less (5.2&#8201;&#177;&#8201;0.6 vs. 8.0&#8201;&#177;&#8201;1.0&#8201;&#181;g&#47;ml, p&#8201;&#60;&#8201;0.05). Conclusion:&#8194; <P></P>Lower plasma adiponectin concentration predicts the clinical efficacy of pioglitazone.",
	pages = "231-233(3)",
	url = "http://www.ingentaconnect.com/content/bsc/dom/2004/00000006/00000003/art00010"
	doi = "doi:10.1111/j.1462-8902.2004.00333.x"
}