IngentaConnect Inverse correlation between activated protein C generation and ca...

Authors: Matsumoto, K.; Yano, Y.; Gabazza, E. C.¹; Araki, R.²; Bruno, N. E.; Suematsu, M.; Akatsuka, H.; Katsuki, A.; Taguchi, O.³; Adachi, Y.; Sumida, Y.

Source: Diabetic Medicine, Volume 24, Number 12, December 2007 , pp. 1322-1328(7)

Publisher: Blackwell Publishing

Abstract:

Aims

Activated protein C (APC) is a key regulator of the clotting system and immune responses. We studied the relationship between the degree of atherosclerosis as measured by the intima-media thickness (IMT) of carotid artery and APC generation in Type 2 diabetic patients. Methods

Eighty-seven Type 2 diabetic patients and 35 control subjects participated. APC generation was assessed by the plasma APC-protein C inhibitor complex (APC-PCI) levels and the mean IMT of carotid artery was measured by ultrasonography. The plasma levels of the thrombin-anti-thromobin complex (TAT) and platelet-derived growth factor (PDGF) were measured by enzyme-linked immunoassays. Results

Plasma TAT levels were significantly higher in diabetic patients [2.03 (1.12, 2.56) ng/ml, median (25th, 75th percentile)] compared with control subjects [0.85 (0.55, 2.08) ng/ml, P < 0.01]. Plasma APC-PCI levels were significantly lower in diabetic patients [0.93 (0.74, 1.22) ng/ml], than in control subjects [1.66 (1.25, 2.36) ng/ml, P < 0.001]. The mean IMT was significantly increased in diabetic patients (0.881 ± 0.242 mm; mean ± sd) compared with control subjects (0.669 ± 0.140 mm; P < 0.01). Univariate analysis showed a significant and inverse correlation between plasma APC-PCI levels and mean IMT (r = -0.32, P < 0.005), and multivariate regression analysis confirmed the independent correlation (P < 0.05). Moreover, plasma APC-PCI levels significantly and inversely correlated with plasma PDGF levels in diabetic patients (r = -0.30, P < 0.01). Conclusions

These results suggest that decreased APC generation is associated with vascular atherosclerotic changes in Type 2 diabetic patients.

Diabet. Med. 24, 1322-1328 (2007)

Keywords: atherosclerosis; intima-media thickness of the carotid artery; Type 2 diabetes

Document Type: Research article

DOI: 10.1111/j.1464-5491.2007.02289.x

Affiliations: 1: Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie, 2: Department of Internal Medicine, National Mie Hospital, Tsu, Mie and 3: Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$50.39 plus tax Refund Policy

Inverse correlation between activated protein C generation and carotid atherosclerosis in Type 2 diabetic patients