Authors: Matsumoto, K.; Yano, Y.; Gabazza, E. C.¹; Araki, R.²; Bruno, N. E.; Suematsu, M.; Akatsuka, H.; Katsuki, A.; Taguchi, O.³; Adachi, Y.; Sumida, Y.

Source: Diabetic Medicine, Volume 24, Number 12, December 2007 , pp. 1322-1328(7)

Publisher: Wiley-Blackwell

Abstract:

Aims 

Activated protein C (APC) is a key regulator of the clotting system and immune responses. We studied the relationship between the degree of atherosclerosis as measured by the intima-media thickness (IMT) of carotid artery and APC generation in Type 2 diabetic patients. Methods 

Eighty-seven Type 2 diabetic patients and 35 control subjects participated. APC generation was assessed by the plasma APC-protein C inhibitor complex (APC-PCI) levels and the mean IMT of carotid artery was measured by ultrasonography. The plasma levels of the thrombin-anti-thromobin complex (TAT) and platelet-derived growth factor (PDGF) were measured by enzyme-linked immunoassays. Results 

Plasma TAT levels were significantly higher in diabetic patients [2.03 (1.12, 2.56) ng/ml, median (25th, 75th percentile)] compared with control subjects [0.85 (0.55, 2.08) ng/ml, P < 0.01]. Plasma APC-PCI levels were significantly lower in diabetic patients [0.93 (0.74, 1.22) ng/ml], than in control subjects [1.66 (1.25, 2.36) ng/ml, P < 0.001]. The mean IMT was significantly increased in diabetic patients (0.881 ± 0.242 mm; mean ± sd) compared with control subjects (0.669 ± 0.140 mm; P < 0.01). Univariate analysis showed a significant and inverse correlation between plasma APC-PCI levels and mean IMT (r = -0.32, P < 0.005), and multivariate regression analysis confirmed the independent correlation (P < 0.05). Moreover, plasma APC-PCI levels significantly and inversely correlated with plasma PDGF levels in diabetic patients (r = -0.30, P < 0.01). Conclusions 

These results suggest that decreased APC generation is associated with vascular atherosclerotic changes in Type 2 diabetic patients.

Diabet. Med. 24, 1322-1328 (2007)

Keywords: atherosclerosis; intima-media thickness of the carotid artery; Type 2 diabetes

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1464-5491.2007.02289.x

Affiliations: 1: Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie, 2: Department of Internal Medicine, National Mie Hospital, Tsu, Mie and 3: Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan

Publication date: 2007-12-01

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• By this author: Matsumoto, K. ;  Yano, Y. ;  Gabazza, E. C. ;  Araki, R. ;  Bruno, N. E. ;  Suematsu, M. ;  Akatsuka, H. ;  Katsuki, A. ;  Taguchi, O. ;  Adachi, Y. ;  Sumida, Y.

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