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Is human Type 2 diabetes maternally inherited? Insights from an animal model

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Aims  Patients with Type 2 diabetes mellitus more often report a history of an affected mother than father. However, in the few studies where both parents and offspring have been directly tested, this apparent maternal excess has not been confirmed. Rodent models of diabetes have the advantage that all parents and offspring can undergo glucose tolerance testing at a specific age in adult life. The aim of this study was to gain insights into the inheritance of human Type 2 diabetes by using a rat model.
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Keywords: diabetes mellitus; inheritance; rodent

Document Type: Research Article

Affiliations: 1: Department of Medicine, University of Wales College of Medicine, Cardiff, Wales, UK and 2: School of Quantitative Methods and Mathematical Sciences, University of Western Sydney, New South Wales, Australia

Publication date: 01 July 2004

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