IngentaConnect Blood glucose overestimation in diabetic patients on continuous a...

Authors: Oyibo S.O.; Pritchard G.M.¹; Mclay L.¹; James E.²; Laing I.²; Gokal R.³; Boulton A.J.M.¹

Source: Diabetic Medicine, Volume 19, Number 8, August 2002 , pp. 693-696(4)

Abstract:

Aims

Diabetic patients on continuous ambulatory peritoneal dialysis (CAPD) for renal failure depend on glucose analysers for regular monitoring of glycaemic control. We aim to inform health professionals of the potentially dangerous overestimation of blood glucose values by some analysers in patients using Icodextrin for dialysis. Methods

Twenty-five patients on continuous ambulatory peritoneal dialysis (10 patients on an 8–12-h nocturnal exchange of Icodextrin) had random glucose analysis performed on venous blood using standardized reference laboratory (lab) technique (glucose oxidase GOD-PAP), and simultaneously on capillary blood using the Precision Q·I·D System (glucose oxidase method) and the Advantage meter (glucose dehydrogenase method). Results

The Precision Q·I·D System agreed with the lab results in both the Icodextrin group and the non-Icodextrin group (80–90% of values fell within 20% of the corresponding lab result). In contrast, the Advantage meter agreed with the lab results only in the non-Icodextrin group (95% of values within 20% of the corresponding lab value), and not in the Icodextrin group, where only 5% of the analyser values fell within 20% of the corresponding lab value. Conclusions

The Precision Q·I·D System, which utilizes glucose oxidase reaction, is safe for use in diabetic patients treated with Icodextrin. All analysers must be cross-checked with the laboratory reference method before use in these patients.

Diabet. Med. 19, 693–696 (2002)

Keywords: glucose analysers; Icodextrin metabolites; pseudo-hyperglycaemia

Document Type: Research article

DOI: 10.1046/j.1464-5491.2002.00753.x

Affiliations: 1: Department of Diabetes, 2: Department of Biochemistry, Manchester Royal Infirmary, Manchester, UK 3: Department of Renal Medicine and

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Blood glucose overestimation in diabetic patients on continuous ambulatory peritoneal dialysis for end-stage renal disease