IngentaConnect A family history of Type 2 diabetes is associated with increased ...

Authors: Pannacciulli N.¹; De Pergola G.; Giorgino F.¹; Giorgino R.¹

Source: Diabetic Medicine, Volume 19, Number 8, August 2002 , pp. 689-692(4)

Abstract:

Aims

The aim of our study was to test whether a family history of Type 2 diabetes (FH) in women is associated with plasma C-reactive protein (CRP). Methods

CRP plasma levels were measured in 162 women, aged 18–60 years; 95 had a positive family history of Type 2 diabetes in a parent or grandparent (FH⁺), and 67 gave no family history of this disease (FH^-). Other measurements included: central fat accumulation, as evaluated by waist circumference; insulin resistance, as calculated by homeostatic model assessment (HOMA_IR); systolic and diastolic blood pressure; and fasting concentrations of glucose, insulin, and lipids. Results

CRP plasma levels were significantly higher in FH⁺ than in FH^- subjects. Moreover, CRP was independently associated with age, body mass index, waist circumference, HOMA_IR, and FH. Conclusions

Our study, performed in a selected population of women free from well-known risk factors for atherothrombosis, demonstrates that subjects with a family history of Type 2 diabetes have higher CRP plasma levels than age- and BMI-matched controls with no family history. Our results show that a family history of Type 2 diabetes is an independent contributor of CRP concentrations, in addition to age, total fatness, central fat accumulation, and insulin resistance.

Diabet. Med. 19, 689–692 (2002)

Keywords: C-reactive protein; family history; diabetes mellitus; insulin resistance; central fat

Document Type: Research article

DOI: 10.1046/j.1464-5491.2002.00770.x

Affiliations: 1: Internal Medicine, Endocrinology, and Metabolic Diseases, Department of Emergency and Transplants, University of Bari, Bari, Italy

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A family history of Type 2 diabetes is associated with increased plasma levels of C-reactive protein in non-smoking healthy adult women