Peripheral blood level alterations of TIMP-1, MMP-2 and MMP-9 in patients with Type 1 diabetes

Authors: Maxwell, P. R.¹; Timms, P. M.²; Chandran, S.³; Gordon, D.³

Source: Diabetic Medicine, Volume 18, Number 10, October 2001 , pp. 777-780(4)

Publisher: Wiley-Blackwell

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Abstract:

Aim

To determine the plasma levels of enzymes and inhibitors involved in extracellular matrix turnover in patients with Type 1 diabetes with normal renal function. Methods

Plasma levels of matrix metalloproteinases 2 and 9 (MMP-2, MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) were measured in 43 Type 1 diabetic subjects and age- and sex-matched controls. Results

No significant difference in plasma MMP-2 between diabetic patients and controls was observed. MMP-9 was detected in the plasma of 15 diabetic patients (35%), but undetectable in all control subjects (P < 0.015). Plasma TIMP-1 concentrations were significantly elevated (P < 0.001) in diabetic patients compared to controls. There was no correlation observed between MMP-2, MMP-9 and TIMP-1 and similarly between MMP-2, MMP-9 and TIMP-1 and age, duration of diabetes, blood pressure and glycated haemoglobin ( HbA_1c). Conclusions

This study has demonstrated alterations in several plasma extracellular matrix modulators in the absence of significant vascular disease.

Diabet. Med. 18, 777-780 (2001)

Keywords: metalloproteinases; Type 1 diabetes

Document Type: Research article

Affiliations: 1: Department of Biochemistry Stobhill Hospital, Glasgow, 2: Department of Biochemistry, St Bartholomew's, London, and 3: Department of Medicine, Stobhill Hospital, Glasgow, UK

Publication date: 2001-10-01