Radicals and oxidative stress in diabetes

Author: West I.C.

Source: Diabetic Medicine, Volume 17, Number 3, March 2000 , pp. 171-180(10)

Publisher: Wiley-Blackwell

Abstract:

Recent evidence is reviewed indicating increased oxidative damage in Type 1 and Type 2 diabetes mellitus as well as deficits in antioxidant defence enzymes and vitamins. Mechanisms are considered whereby hyperglycaemia can increase oxidative stress, and change the redox potential of glutathione and whereby reactive oxygen species can cause hyperglycaemia. It is argued that oxygen, antioxidant defences, and cellular redox status should now be regarded as central players in diabetes and the metabolic syndrome.

Keywords: ascorbic acid; diabetes mellitus; glutathione; lipoate; oxidative stress; reactive oxygen species; vitamin E

Language: English

Document Type: Research article

Publication date: 2000-03-01

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• In this Subject: Internal Medicine
• By this author: West I.C.

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