Ions, genes and insulin release: from basic science to clinical disease Based on the 1998 R. D. Lawrence Lecture

Author: Dunne M.J.

Source: Diabetic Medicine, Volume 17, Number 2, February 2000 , pp. 91-104(14)

Publisher: Wiley-Blackwell

Abstract:

In 1968, reports of the first microelectrode recordings of insulin-secreting cells were published. Thirty years later it is now established that electrical responses of -cells play a critical role in stimulus-secretion coupling. It is now also clear that defects in ion channel genes compromise the mechanisms which govern secretion and lead to the onset of disease. Here, the physiology of insulin release is reviewed in the context of ion channels, the ionic control of insulin release and the pathophysiology of hyperinsulinism of infancy.

Keywords: diazoxide; hyperinsulinism; insulin secretion; K_ATP channels; neonatal hypoglycaemia; sulphonylurea

Language: English

Document Type: Review article

Publication date: 2000-02-01

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