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Free Content Decreased in vitro fertilization efficiencies in the presence of specific cyritestin peptides

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Abstract:

Synthetic peptides corresponding to specific regions of the mouse acrosomal transmembrane protein cyritestin have been used as competitors in in vitro fertilization experiments. One peptide representing a putative egg-receptor binding site within the disintegrin domain of cyritestin lowered the fertilization rate to 30% of the normal value.

Keywords: disintegrin; integrins; metalloproteinase; mouse testis; spermatogenesis

Document Type: Research Article

DOI: http://dx.doi.org/10.1046/j.1440-169X.1997.t01-1-00013.x

Affiliations: Institut für Genetik, Heinrich-Heine-Universität, D-40225 Düsseldorf, Germany.

Publication date: April 1, 1997

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