Horner syndrome

Authors: Kong, Yu X; Wright, Gavin¹; Pesudovs, Konrad²; O'Day, Justin; Wainer, Zoe³; Weisinger, Harrison S³

Source: Clinical & Experimental Optometry, Volume 90, Number 5, September 2007 , pp. 336-344(9)

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Abstract:

Horner syndrome is an uncommon but important clinical entity, representing interruption of the sympathetic pathway to the eye and face. Horner syndrome is almost always diagnosed clinically, though pharmacological testing can be used to confirm the diagnosis. Imaging modalities such as PET, CT and MRI are important components of work-up for patients presenting with acquired Horner syndrome. Our patient's presentation with Horner syndrome unmasked the causative superior sulcus squamous cell carcinoma and a coincidental lower lobe adenocarcinoma. Successful radical treatment of these cancers resulted in complete resolution of the syndrome and disease-free survival at 18 months. We review the anatomy and pathophysiology underlying this and other causes of Horner syndrome.

Keywords: Horner syndrome; miosis; ptosis; superior pulmonary sulcus tumour; sympathetic nervous system

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1444-0938.2007.00177.x

Affiliations: 1: Cardiothoracic Care Centre, 2: NH&MRC Centre for Clinical Eye Research, Department of Ophthalmology, Flinders Medical Centre, Flinders University, Bedford Park, SA, Australia 3: St. Vincent's Hospital, Fitzroy, Victoria, Australia

Publication date: 2007-09-01