Biofilm formation and prevalence of lukF-pv, seb, sec and tst genes among hospital- and community-acquired isolates of some international methicillin-resistant Staphylococcus aureus lineages

Authors: Souza, R. R.¹; Coelho, L. R.¹; Botelho, A. M. N.¹; Ribeiro, A.¹; Rito, P. N.²; Vieira, V. V.²; Teixeira, L. A.³; Ferreira-Carvalho, B. T.¹; Figueiredo, A. M. S.¹

Source: Clinical Microbiology & Infection, Volume 15, Number 2, February 2009 , pp. 203-207(5)

Publisher: Wiley-Blackwell

Abstract:

Methicillin-resistant Staphylococcus aureus (MRSA) is an important nosocomial agent of biopolymer-associated infections, and isolates of S. aureus can produce different virulence factors, including potent toxins. The biofilm formation and accumulation by certain international MRSA lineages were analysed, and the toxic shock syndrome-associated genes (tst, seb and sec) among these isolates were assessed. In addition, the presence of lukF-pv (encoding the F-subunit of Panton-Valentine leukocidin (PVL)) was investigated. Most of the MRSA isolates tested were capable of forming biofilm on polystyrene surfaces, but lacked the superantigen toxin genes that were tested. PVL was rarely detected among the hospital isolates analysed.

Keywords: Biofilm; MRSA; MSSA; PVL; S. aureus; virulence factors

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1469-0691.2008.02118.x

Affiliations: 1:  Departamento de Microbiologia Médica, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Bloco I, Cidade Universitária 2:  Instituto Nacional de Controle em Qualidade em Saúde, Rio de Janeiro, RJ 3:  Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brazil

Publication date: 2009-02-01

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• By this author: Souza, R. R. ;  Coelho, L. R. ;  Botelho, A. M. N. ;  Ribeiro, A. ;  Rito, P. N. ;  Vieira, V. V. ;  Teixeira, L. A. ;  Ferreira-Carvalho, B. T. ;  Figueiredo, A. M. S.

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