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Pertussis in young infants: apnoea and intra-familial infection
Authors: Raymond, J.1; Armengaud, J.-B.2; Cosnes-Lambe, C.2; Chalumeau, M.2; Bosdure, E.2; Reglier-Poupet, H.1; El Hajje, M.-J.2; Iniguez, J.-L.2; Moulin, F.2; Poyart, C.1; Gendrel, D.2
Source: Clinical Microbiology & Infection, Volume 13, Number 2, February 2007 , pp. 172-175(4)
Publisher: Wiley-Blackwell
Abstract:
This study investigated 41 infants, aged <4 months, who were hospitalised with symptoms compatible with pertussis. Of these, 16 had Bordetella pertussis infection confirmed by real-time PCR. For four of these 16 patients, the initial sample was PCR-negative, but samples collected 5-7 days after the onset of infection were PCR-positive. PCR was also positive with samples from 15/16 families and 20/41 household contacts. Nine of the 20 positive household contacts were asymptomatic. Among the 16 infants with proven pertussis, apnoea was more frequent than in a control group for whom PCR was negative with both children and household contacts (69% vs. 28%). It was concluded that real-time PCR performed with samples from household contacts facilitates the diagnosis of infants suspected clinically of having pertussis, thereby enabling earlier treatment.Keywords: Apnoea; Bordetella pertussis; household contacts; infants; pertussis; real-time PCR
Document Type: Research article
DOI: http://dx.doi.org/10.1111/j.1469-0691.2006.01616.x
Affiliations: 1: Laboratoire de Bacteriologie 2: Service de Pédiatrie Générale et Laboratoire d'Épidémiologie Clinique Pédiatrique, Université Paris 5, Hôpital Saint Vincent de Paul-Cochin, Paris, France
Publication date: 2007-02-01
- In this: publication
- By this: publisher
- In this Subject: Microbiology
- By this author: Raymond, J. ; Armengaud, J.-B. ; Cosnes-Lambe, C. ; Chalumeau, M. ; Bosdure, E. ; Reglier-Poupet, H. ; El Hajje, M.-J. ; Iniguez, J.-L. ; Moulin, F. ; Poyart, C. ; Gendrel, D.
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