Prevalence of inducible clindamycin resistance in macrolide-resistant Staphylococcus spp.

Authors: Fokas, S.; Tsironi, M.; Kalkani, M.; Dionysopouloy, M.

Source: Clinical Microbiology & Infection, Volume 11, Number 4, April 2005 , pp. 337-340(4)

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Abstract:

Between January 2002 and December 2003, macrolide-resistant isolates of Staphylococcus aureus (n = 45) and coagulase-negative staphylococci (CoNS; n = 75) from a Greek hospital were examined phenotypically for inducible clindamycin resistance. The constitutive macrolide resistance phenotype predominated (60%) in S. aureus, followed by the inducible (35%) and the clindamycin-susceptible (5%) phenotypes. In CoNS, the inducible phenotype was more common than the constitutive phenotype (50% vs. 41%). There was a significant incidence of inducible clindamycin resistance, and screening of all staphylococci is necessary in order to differentiate inducibly resistant isolates from those that are truly sensitive.

Keywords: Clindamycin resistance; coagulase-negative staphylococci; macrolide resistance; resistance; Staphylococcus aureus; susceptibility testing

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1469-0691.2005.01101.x

Publication date: 2005-04-01