Macrolide-resistance mechanisms in Streptococcus pneumoniae isolates from Belgium

Authors: Van Eldere, J.¹; Meekers, E.¹; Lagrou, K.¹; Massonet, C.¹; Canu, A.²; Devenyns, I.¹; Verhaegen, J.¹; Syrogiannopoulos, G.³; Leclercq, R.²

Source: Clinical Microbiology & Infection, Volume 11, Number 4, April 2005 , pp. 332-334(3)

Publisher: Blackwell Publishing

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Abstract:

Of 233 erythromycin-resistant pneumococcal isolates collected in Belgium in 1999–2000, 89.7% carried the erm(B) gene, 6% the mef(A) gene, and 3.5%erm(B) plus mef(A). Two isolates contained neither erm(B) nor mef(A); one contained an erm(A) subclass erm(TR) gene, while the other contained an A2058G mutation in domain V of the 23S rRNA gene. Of 209 erm(B)-positive isolates, 191 had clindamycin MICs > 16 mg/L and 18 had MICs ≤ 16 mg/L. Mef(A)-positive isolates all displayed the M resistance phenotype. Telithromycin remained active against erythromycin-resistant isolates, with the highest telithromycin MIC₅₀ being found in mef(A)-positive isolates. No difference in the prevalence of different resistance mechanisms was observed compared to isolates collected in 1995–1997.

Keywords: erm(B); macrolide resistance; mef(A); pneumococci; resistance; Streptococcus pneumoniae

Document Type: Research article

DOI: 10.1111/j.1469-0691.2005.01077.x

Affiliations: 1: Department of Microbiology and Immunology, Katholieke Universiteit Leuven, Leuven, Belgium 2: Laboratoire de Microbiologie, CHU de Caen, Caen, France 3: Department of Paediatrics, General University Hospital, University of Patras, School of Medicine, Patras, Greece