IngentaConnect The 1246GA polymorphism of the HCRTR2 gene is not associated with...

Authors: Pinessi, L; Binello, E; De Martino, P; Gallone, S; Gentile, S; Rainero, I; Rivoiro, C; Rubino, E; Savi, L; Valfrè, W; Vaula, G

Source: Cephalalgia, Volume 27, Number 8, August 2007 , pp. 945-949(5)

Publisher: Blackwell Publishing

Abstract:

Pinessi L, Binello E, De Martino P, Gallone S, Gentile S, Rainero I, Rivoiro C, Rubino E, Savi L, Valfrè W & Vaula G. The 1246G→A polymorphism of the HCRTR2 gene is not associated with migraine. Cephalalgia 2007; 27:945-949. London. ISSN 0333-1024

Studies in experimental animals have suggested that the hypocretin/orexin system may be involved in migraine pathophysiology. Using a case-control design study, we genotyped 246 migraine patients and 239 healthy controls for the 1246G→A polymorphism of the hypocretin receptor 2 (HCRTR2) gene. Genotypic and allelic frequencies of the examined polymorphism were similarly distributed between cases and controls (χ² = 2.22, P = 0.14 and χ² = 2.45, P = 0.29, respectively). When different migraine subgroups were compared (migraine with aura vs. migraine without aura and episodic vs. chronic migraine) no significant difference was found. Comparison of the clinical features of the disease with the 1246G→A genotypes showed no significant difference. Our data suggest that the HCRTR2 gene is not a genetic risk factor in migraine.

Keywords: Hypocretin receptor 2 gene; migraine; migraine with aura; migraine without aura; polymorphism

Document Type: Research article

DOI: 10.1111/j.1468-2982.2007.01347.x

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The 1246G→A polymorphism of the HCRTR2 gene is not associated with migraine