EFFECT OF STATIN THERAPY ON PLASMA HIGH-DENSITY LIPOPROTEIN-CHOLESTEROL LEVELS IS MODIFIED BY PARAOXONASE 1 IN CHINESE PATIENTS WITH CORONARY HEART DISEASE

Authors: Fu, Ran; Sun, Yan-Ming; Su, Ying; Wu, Yun; Luan, Ying

Source: Clinical and Experimental Pharmacology and Physiology, Volume 35, Number 8, August 2008 , pp. 982-983(2)

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Abstract:

SUMMARY

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We sought to determine the effects of Q192R polymorphism of paraoxonase 1 (PON1) gene on plasma high-density lipoprotein-cholesterol (HDL-C) levels and the response to statin therapy in Chinese patients with coronary heart disease (CHD).

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Two hundred and thirty-six patients with CHD were treated with simvastatin 20 mg/day. Fasting serum lipids were determined before and after 12 weeks of treatment.

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No significant differences were detected among the PON1 Q192R polymorphism with respect to plasma lipids. In addition, the effects of simvastatin to increase HDL-C levels were significantly greater in patients with the RR genotype compared with patients with the QR or RR genotypes (P < 0.05).

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We conclude that the Q192R polymorphism of PON1 significantly modulates the HDL-C response to simvastatin in Chinese patients with CHD.

Keywords: coronary heart disease; genetic polymorphism; 3-hydroxy-3-methylglutaryl coenzyme A reductse inh; paraoxonase

Document Type: Short communication

DOI: http://dx.doi.org/10.1111/j.1440-1681.2008.04941.x

Publication date: 2008-08-01