5-HT₇, NEUROGENESIS AND ANTIDEPRESSANTS: A PROMISING THERAPEUTIC AXIS FOR TREATING DEPRESSION

Authors: Nandam, L Sanjay; Jhaveri, Dhanisha; Bartlett, Perry

Source: Clinical and Experimental Pharmacology and Physiology, Volume 34, Numbers 5-6, May 2007 , pp. 546-551(6)

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Abstract:

SUMMARY

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There is mounting evidence that a wide range of antidepressants share the common feature of increasing hippocampal neurogenesis. The specificity of this association has suggested that an ability to increase neurogenesis might be a useful paradigm to screen for compounds with antidepressant activity.

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The hope of developing better antidepressants has stimulated research into the molecular control of neurogenesis and here we summarize some of the recent findings. We also review recent work that highlights 5-HT₇ receptor as a promising molecular target in the treatment of depression.

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In summary, it appears that 5-HT₇ antagonism is capable of producing diverse antidepressant-like behavioural effects, alters hippocampal neuronal morphology and synergistically regulates hippocampal neurogenesis.

Keywords: 5-HT7; antidepressants; depression; hippocampus; neural precursor; neurogenesis; proliferation; serotonin; subventricular zone

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1440-1681.2007.04608.x

Publication date: 2007-05-01