SPECIES VARIABILITY IN CARDIOVASCULAR RESEARCH: THE EXAMPLE OF ADRENOCORTICOTROPHIN-INDUCED HYPERTENSION

Authors: Whitworth, Judith A; Zhang, Yi; Mangos, George; Kelly, John J

Source: Clinical and Experimental Pharmacology and Physiology, Volume 33, Number 9, September 2006 , pp. 887-891(5)

Publisher: Wiley-Blackwell

Abstract:

SUMMARY

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Lawrie Beilin has contributed greatly to international hypertension research through both animal and human studies.

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Animals are used in biomedical research to gain insights that can be extrapolated ultimately to humans.

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A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species.

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Caution should be exercised in extrapolating data from animals to humans.

Keywords: blood pressure; dog; humans; mouse; rat; sheep; steroids

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1440-1681.2006.04460.x

Publication date: 2006-09-01

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