IngentaConnect Different remodelling against left ventricular overload between d...

Abstract:

Summary

1. Diabetes mellitus is significantly associated with the occurrence of congestive heart failure in end-stage renal disease patients undergoing maintenance haemodialysis. In the present study, we asked whether the left ventricular remodelling against sustained pressure and/or volume overload to the left ventricle may be different between diabetic and non-diabetic haemodialysis patients.

2. Left ventricular parameters, including left ventricular mass index (LVMI), interventricular septal wall thickness (IVST) and relative left ventricular wall thickness (rLVWT), were assessed in 486 patients receiving maintenance haemodialysis (145 diabetic and 341 non-diabetic patients) using transthoracic echocardiography. Plasma concentrations of B-type natriuretic peptide (BNP), measured with an immunoradiometric assay, were used as a humoral parameter indicating left ventricular wall stress.

3. In non-diabetic patients, the plasma BNP concentration correlated with LVMI (r = 0.245; P = 0.0001), IVST (r = 0.250; P = 0.0001) and rLVWT (r = 0.149; P = 0.006). Furthermore, LVMI was correlated with mean blood pressure and pulse pressure and IVST and rLVWT were correlated with pulse pressure.

4. In contrast, none of the measured factors was correlated with LVMI and IVST in diabetic patients. Plasma BNP concentrations were positively correlated with end-systolic and end-diastolic left intraventricular dimensions and were inversely correlated with rLVWT and left ventricular fractional shortening in diabetic patients, but not in non-diabetic patients.

5. In conclusion, a sustained increase in left ventricular wall stress is likely to elicit eccentric left ventricular remodelling in diabetic haemodialysis patients, whereas it causes concentric left ventricular remodelling in non-diabetic haemodialysis patients. This difference in left ventricular remodelling against left ventricular overload may be associated with the high incidence of congestive heart failure in diabetic haemodialysis patients.

Keywords: B-type natriuretic peptide; congestive heart failure; diabetes mellitus; end-stage renal disease; haemodialysis; left ventricular hypertrophy; remodelling

Document Type: Research article

DOI: 10.1046/j.1440-1681.2003.03914.x

Affiliations: 1: Cardiovascular Division, 2: Division of Urology and 3: Division of Surgery, Toujinkai Hospital, 4: The First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto and 5: Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University, Osaka, Japan

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Different remodelling against left ventricular overload between diabetic and non-diabetic haemodialysis patients