Type IV Phosphodiesterase Inhibitor Suppresses Insulin-Dependent Myocardial Glucose Uptake

Authors: Imahashi K.; Yoshioka J.; Yamakita T.; Yamano S.; Kusuoka H.; Nishimura T.

Source: Clinical and Experimental Pharmacology and Physiology, Volume 28, Number 4, April 2001 , pp. 290-291(2)

Publisher: Blackwell Publishing

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Abstract:

SUMMARY

1. Phosphodiesterase (PDE) IV has been localized at cardiomyocytes and the coronary vasculature and modulates cAMP, but the effect of PDE IV on myocardial glucose uptake has not been demonstrated.

2. Glucose uptake in rat isolated hearts treated with the PDE IV inhibitor rolipram was measured by [³¹P] nuclear magnetic resonance spectroscopy.

3. Under non-stimulating conditions, glucose uptake was not significantly different between control and rolipram (1 mol/L)-treated rat hearts, whereas enhanced uptake in insulin-stimulated conditions was significantly attenuated by rolipram.