Blood flow in the peripapillary retina in exfoliation glaucoma

Authors: Harju, Mika; Kurvinen, Leena; Saari, Jukka; Vesti, Eija

Source: Clinical & Experimental Ophthalmology, Volume 36, Number 8, November 2008 , pp. 738-743(6)

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Abstract:

Purpose:

The aim of this article is to study peripapillary retinal blood flow in patients with progressive and stable exfoliation glaucoma (ExG). Methods:

Fifty-eight eyes with ExG were included; 25 of them had progressive and 33 stable glaucoma. Retinal blood flow in the peripapillary retina was measured with scanning laser Doppler flowmetry. Acquired flow maps were analysed with the automatic full-field perfusion image analyser. Multiple logistic regression was used to model progression of glaucoma. Results:

Mean retinal flow (MF; correlation coefficient, P-value; R = 0.36, P = 0.006) and retinal minimum diastolic flow (R = 0.33, P = 0.011) were positively correlated with visual field mean defect (MD). Factors associated with progressive glaucoma were mean intraocular pressure (OR = 1.198 for each mmHg; P = 0.050) and visual field MD (OR = 1.134 for each dB; P = 0.013). Age (P = 0.35), MF (P = 0.58), or presence of cardiovascular disease (P = 0.17) were not associated with glaucoma progression. Conclusion:

No difference in peripapillary retinal blood flow between progressive and stable ExG could be found.

Keywords: blood flow; exfoliation glaucoma; Heidelberg retina flowmeter; peripapillary retinal blood flow; pseudoexfoliation

Document Type: Original article

DOI: http://dx.doi.org/10.1111/j.1442-9071.2008.01884.x

Publication date: 2008-11-01