Comparison of posterior capsule opacification in rabbits receiving either mitomycin-C or distilled water for sealed-capsule irrigation during cataract surgery

Authors: Kim, Su-Young¹; Kim, Jin-Hyung²; Choi, Jun-Sub³; Joo, Choun-Ki

Source: Clinical & Experimental Ophthalmology, Volume 35, Number 8, November 2007 , pp. 755-758(4)

Publisher: Wiley-Blackwell

Abstract:

Purpose: 

To compare posterior capsule opacification (PCO) in rabbits who undergo cataract surgery and receive either mitomycin-C (MMC) or distilled water (DW) during sealed-capsule irrigation (SCI). In addition, we examined the toxicity of DW and MMC. Methods: 

Twenty-four eyes from 12 rabbits were divided into three groups. Balanced salt solution (BSS), DW, MMC 0.4 mg/mL was injected into the capsular bag for 2 min after endocapsular phacoemulsification and insertion of a SCI device. The degree of PCO was assessed by POCOman software at 3 months post surgery. Central corneal thickness, anterior chamber inflammation were assessed 1 day, 1 week, 2 weeks, 3 weeks, 1 month and 3 months postoperatively. Results: 

A statistically significant difference in PCO scores was noted between the control and study groups (P < 0.05). The PCO scores of the MMC group were significantly lower than those of the DW group (P < 0.05). The MMC and DW groups did not show significant toxicity compared with the BSS group. Conclusions: 

MMC is more effective in reducing PCO than DW; the SCI device can protect the surrounding ocular tissue from MMC toxicity in rabbit eyes.

Keywords: mitomycin-C; posterior capsule opacification; sealed-capsule irrigation

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1442-9071.2007.01588.x

Affiliations: 1: Department of Ophthalmology and Visual Science and 2: Department of Ophthalmology, Ilsan Paik Hospital, College of Medicine, Inje University, Gyeonggido, Korea 3: Laboratory of Visual Science, College of Medicine, The Catholic University of Korea, Seoul, and

Publication date: 2007-11-01

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• In this Subject: Anatomy & Physiology ,  Ophthalmology
• By this author: Kim, Su-Young ;  Kim, Jin-Hyung ;  Choi, Jun-Sub ;  Joo, Choun-Ki

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