Methotrexate-induced optic neuropathy

Authors: Balachandran, Chandra¹; McCluskey, Peter J; Champion, G David²; Halmagyi, G Michael³

Source: Clinical & Experimental Ophthalmology, Volume 30, Number 6, December 2002 , pp. 440-441(2)

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Abstract:

A 53-year-old Caucasian woman with long-standing, well controlled, severe rheumatoid arthritis, treated with methotrexate, salazopyrin, naprosyn, prednisone and plaquenil, presented with progressive visual loss in each eye. She had a past history of non-necrotizing anterior scleritis that was treated with increased doses of prednisone. She developed left then right central scotomas, reduced vision and optic atrophy. Eventually a diagnosis of methotrexate-induced optic atrophy was made.

Keywords: methotrexate; optic neuropathy; rheumatoid arthritis; side-effect

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1442-9071.2002.00578.x

Affiliations: 1: Department of Ophthalmology and 2: Rheumatology, St Vincent's Hospital, Sydney, New South Wales, Australia 3: Institute of Clinical Neuroscience, Royal Prince Alfred Hospital, and Departments of

Publication date: 2002-12-01