The contribution of cone responses to rat electroretinograms

Authors: Nixon, Peter J; Bui, Bang V; Armitage, James A; Vingrys, Algis J

Source: Clinical & Experimental Ophthalmology, Volume 29, Number 3, June 2001 , pp. 193-196(4)

Publisher: Wiley-Blackwell

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The contribution of rods and cones to the scotopic electroretinogram (ERG) of small animals is unclear, with a recent report suggesting that the mouse has no cone a-wave. The present study considered the contribution of cones to the ERG of the rat. Dark-adapted Long Evans rats (n = 4) had ERG signals collected following a single flash, which stimulated rods and cones (mixed response), or a twin-flash paradigm (short interstimulus interval, 1 s), which isolated cone responses. Rod signals were derived by digital subtraction of the cone signal from the mixed rod/cone ERG. The rat a-wave was found to be dominated by rod responses but cone responses contributed substantially (45%) to post-receptoral waveforms (b-wave) at higher light levels.

Keywords: cone; electroretinogram; rat; rod

Document Type: Research Article


Publication date: June 1, 2001

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