Co-existence of Hashimoto's thyroiditis with familial Mediterranean fever: is there a pathophysiological association between the two diseases?

Authors: Gulcan, E.¹; Gulcan, A.²; Koplay, M.³; Alcelik, A.⁴; Korkmaz, U.⁵

Source: Clinical & Experimental Immunology, Volume 156, Number 2, May 2009 , pp. 373-376(4)

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Abstract:

Summary

Familial Mediterranean fever is an autosomal recessive disease characterized by periodic attacks of fever and polyserositis, while Hashimoto's thyroiditis is the most common cause of hypothyroidism. We suggest that common autoimmune mechanisms may underlie both disorders, describe their clinical co-existence in a patient, and discuss a possible causal link between them.

Keywords: associated diseases; autoimmunity; cytokines; familial Mediterranean fever; Hashimoto's thyroiditis

Document Type: Dissertation

DOI: http://dx.doi.org/10.1111/j.1365-2249.2009.03891.x

Affiliations: 1: Department of Internal Medicine, Dumlupinar University School of Medicine, Kutaya, Turkey, 2: Kutahya State Hospital, Department of Microbiology and Clinical Microbiology, Kutahya, Turkey, 3: Department of Radiology, Dumlupinar University School of Medicine, Kutahya, Turkey, 4: Specialist MD Duzce State Hospital, Department of Internal Medicine, Duzce, Turkey, and 5: Department of Gastroenterology, Osman Gazi University, Eskisehir, Turkey

Publication date: 2009-05-01