Warfarin skin necrosis associated with protein S deficiency and a mutation in the methylenetetrahydrofolate reductase gene

Authors: Byrne J.S.; Abdul Razak A.R.; Patchett S.; Murphy G.M.

Source: Clinical & Experimental Dermatology, Volume 29, Number 1, January 2004 , pp. 35-36(2)

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Abstract:

Summary

The use of warfarin is rarely complicated by skin necrosis. We describe a 50-year-old woman who presented with a left leg deep venous thrombosis and subsequent pulmonary embolism. She was initially anticoagulated with low-molecular weight heparin and subsequently warfarin. Within 4 days abdominal skin necrosis developed. Investigations revealed the presence of protein S deficiency and in addition, a mutation in the methylenetetrahydrofolate reductase gene (MTHFR). We present, to our best knowledge, the first case of warfarin skin necrosis associated with a methylenetetrahydrofolate reductase mutation.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-2230.2004.01443.x

Affiliations: 1: Department of Gastroenterology & General Medicine, Beaumont Hospital, Dublin 9, Ireland

Publication date: 2004-01-01