The relationship between tumour proliferative activity, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer
Source: Colorectal Disease, Volume 10, Number 7, September 2008 , pp. 663-667(5)
The aim of the present study was to examine the relationship between Ki-67, C-reactive protein and cancer-specific survival in patients undergoing resection for colorectal cancer. Method
One hundred and forty-seven patients undergoing potentially curative resection for colorectal cancer had preoperative C-reactive protein concentrations and tumour Ki-67 labelling index measured. Results
On univariate analysis, age (P < 0.001), Dukes stage (P < 0.001), C-reactive protein (P < 0.001) and expression of Ki-67 (< 0.01) were associated with poorer cancer-specific survival. Ki-67 labelling index and C-reactive protein were correlated (rs = 0.172, P = 0.037). On multivariate analysis, age (HR 1.96, 95% CI 1.26–3.04, P = 0.003), Dukes stage (HR 4.38, 95% CI 2.11–9.09, P < 0.001) and C-reactive protein (HR 4.09, 95% CI 2.04–8.24, P < 0.001) retained significance. Conclusion
Increased tumour proliferation is associated with a systemic inflammatory response and poor cancer-specific survival in patients undergoing potentially curative surgery for colorectal cancer.
Document Type: Research Article
Publication date: September 2008