Skip to main content

The relationship between tumour proliferative activity, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Abstract Background 

The aim of the present study was to examine the relationship between Ki-67, C-reactive protein and cancer-specific survival in patients undergoing resection for colorectal cancer. Method 

One hundred and forty-seven patients undergoing potentially curative resection for colorectal cancer had preoperative C-reactive protein concentrations and tumour Ki-67 labelling index measured. Results 

On univariate analysis, age (P < 0.001), Dukes stage (P < 0.001), C-reactive protein (P < 0.001) and expression of Ki-67 (< 0.01) were associated with poorer cancer-specific survival. Ki-67 labelling index and C-reactive protein were correlated (rs = 0.172, P = 0.037). On multivariate analysis, age (HR 1.96, 95% CI 1.26–3.04, P = 0.003), Dukes stage (HR 4.38, 95% CI 2.11–9.09, P < 0.001) and C-reactive protein (HR 4.09, 95% CI 2.04–8.24, P < 0.001) retained significance. Conclusion 

Increased tumour proliferation is associated with a systemic inflammatory response and poor cancer-specific survival in patients undergoing potentially curative surgery for colorectal cancer.

Keywords: C-reactive protein; Dukes stage; Ki-67; colorectal cancer; survival

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1463-1318.2007.01416.x

Affiliations: 1: University Departments of Surgery 2: Pathology, Royal Infirmary, Glasgow, UK

Publication date: 2008-09-01

  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more