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Aetiology and surgical management of toxic megacolon

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Abstract Objective 

The purpose of this article is to review the surgical management and outcome of toxic megacolon and to update the aetiology of toxic megacolon. Patients and method 

A retrospective chart review of three academic colorectal surgery units was undertaken. Over a period of 20 years, 70 patients with surgically managed toxic megacolon were identified: 32 men and 38 women, median age 63 years (range, 23–87 years). Results 

In 33 (48%) patients the main cause of toxic megacolon was inflammatory bowel disease. Thirty-seven (52%) patients had toxic megacolon of different aetiology. Sixty-three patients underwent colonic resection: 49 (70%) subtotal colectomies and 14 (20%) total colectomies, including 4 (6%) proctocolectomies. Seven (10%) patients had decompression (n = 3) or faecal diversion (n = 4) only. Forty-four of the resected patients underwent a Hartmann's procedure and an ileostomy; 13 (19%) patients had primary anastomoses, 11 (16%) ileorectal anastomoses (IRA) and 2 (3%) patients had ileal pouch-anal anastomosis (IPAA). Twenty-six (37%) patients subsequently had continuity restored. Total surgical complication rate was 19% (n = 13), 8% (n = 4) in patients treated with subtotal colectomy, 21% (n = 3) in patients treated with total proctocolectomy and 86% (n = 6) in patients treated with either decompression or diversion. The total mortality rate was 16% (n = 11). Conclusions 

Toxic colitis complicated by toxic megacolon can occur after various diseases of the colon and remains a life-threatening disorder associated with a significant risk of postoperative complications. Subtotal colectomy with ileostomy remains the procedure of choice. Surgical colonic decompression with faecal diversion alone is associated with a high rate of complications.
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Keywords: Toxic megacolon; aetiology; surgical management

Document Type: Research Article

Affiliations: 1: Department of Surgery, Danube Hospital 2: Department of Surgery, Division of Colon and Rectal Surgery, University of Minnesota Medical School, Minneapolis, Minnesota, USA 3: Department of General Surgery, Medical University of Vienna, Vienna, Austria

Publication date: 01 March 2006

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